Prof. Dr. Klaus Mayerhofer about MENOPEARL®

Prof. Dr. Doris Maria Gruber, MD

Talking about MENOPEARL® with Prof. Doris Maria Gruber, MD – An expert in the field of menopause

Women today talk openly about menopause: What do you think about it?

Women with their manifold menopausal complaints finally dare to turn to their doctors with hope again and say openly when they feel bad and that they need help. One third of the women are doing well in menopause, 1/3 want to do a little something because they feel the first signs, and the remaining third ask for advice to try hormone replacement therapy after all because of the severe complaints.

To whom would you recommend MENOPEARL®?

There is something suitable for all women. For women with mild to moderate complaints who do not like to use hormones, MENOPEARL® is ideal! In general, isoflavones work very well. However, women need some patience. Isoflavones have experienced a massive upswing in recent years – the scientific data is excellent! Women trust in phytotherapy – which includes isoflavones – and if they also improve the appearance of the skin at the same time, that is ideal. The composition of red clover isoflavones (MF11RCE®) and low molecular weight hyaluronic acid in MENOPEARL® is just optimal!

I recommend taking MENOPEARL® for at least 3 months! It is important to point out that it takes some time until the supporting effect of MENOPEARL® to fully develop. An important issue in any therapy is always the question of bleeding intervals. If there is no bleeding for a longer time period, one can assume that it will remain that way with this form of therapy.

Can you tell us about a specific experience with MENOPEARL® from one of your patients?

I have a patient who has been taking MENOPEARL® for 2 years and is very satisfied with it! She swears that her skin appearance has improved and you also notice that she always looks fresh and vital! In addition, she also has no more bleeding.

There is extensive study data on the standardized MF11RCE® red clover extract contained in MENOPEARL® and its origin is openly communicated: How interesting is this for you?

I think it is very good when companies provide precise information about the origin and quality of their product (where it comes from, how is it manufactured, etc.). If there is also scientific data about a product, this creates of course a trust with the patient!

What would you say is special about MENOPEARL®?

The product composition consisting of a standardized, study-proven red clover extract and a bioavailable hyaluronic acid is very exceptional! It is a product that can cover a special patient group – especially for patients who are uncertain about menopause, hormones, etc., MENOPEARL® is just great! MENOPEARL® creates confidence in a therapy without having to reach straight into the hormone pot right away!

Prim Univ.-Prof. Dr. Martin Imhof
(Department for gynecology, General Public Teaching Hospital Korneuburg, Austria)

«The study has confirmed that an early, individualized therapy provides clear benefit. This significant scientific study allows us to show that MF11RCE®-Isoflavone considerably reduces menopausal complaints without side effects. MF11RCE® thus appears to be a very suitable first-line therapy for menopausal complaints and, based on its effectiveness as a “selective estrogen receptor modulator” (SERM), forms the ideal prerequisites to also complement a synthetic estrogen.»

Lipovac M. et al., Gynecol Endocrinol. 2012 Mar 28(3): 203-207.

Univ.-Prof. Dr. Christian Simhandl
(Bipolar center Wiener Neustadt, Austria)

«The study shows that with red clover extract psychological complaints such as anxiety and depression in menopause can be successfully and expediently tackled without hormone replacement therapy or psychotropic treatment. In 109 women, the changes in the parameters related to depression and anxiety collected in the self-assessment were clearly and clinically relevant compared to the placebo. We should thus be encouraged to successfully treat psychological complaints like anxiety and depression with red clover extract in the early stages of menopause.»

Lipovac M. et al. Maturitas 2010 Mar 65(3): 258-261.

Dr. Peter Chedraui
(Medical University de Santiago de Guayaquil, Ecuador)

«After three months of MF11RCE® supplements, the women reported a subjective improvement to their scalp and the condition of their skin. In addition to this, their libido, mood, sleep and levels of tiredness improved. It is interesting to note that this is just the first study which demonstrates the effectiveness of MF11RCE® on post-menopausal women. It shows MF11RCE® to be an attractive therapeutic option, in particular for women for whom a conventional estrogen therapy is contraindicated, or for those for whom it is not suitable.»

Chedraui P. et al. Int J Gynaecol Obstet. 2006 Dec 95(3): 296-7.

Univ.-Prof. Dr. Dr. h.c. Heinz Kölbl
(Department for general gynecology and gynecological oncology, Medical University of Vienna, Austria)

«The present results emphasize the significance of the urogenital atrophy and its treatment. The data relating to treatment with red clover extract (MF11RCE®) is compelling. The key symptoms of vaginal dryness and increase in libido go hand in hand with the evidence of cytological changes as hard parameters of effectiveness. These studies should provide motivation to study the favorable effects of the substance also with regard to functionality of the pelvic organs (bladder, bowels).»

Chedraui P. et al. Int J Gynaecol Obstet. 2006 Dec 95(3): 296-7.

Univ.-Prof. DDr. Johannes Huber
(Specialist in gynecology and obstetrics, Vienna, Austria)

«The study confirms the statement of the European Food Safety Authority (EFSA) which studied the ingredients of red clover extracts for their side effects with regard to breast, thyroid and endometrium. It determined that none of the three organ systems are afflicted, damaged by or at risk from these plant substances. The results furthermore show that isoflavones clearly also have an aromatase inhibiting effect, which should be further evaluated in future.»

Imhof M. et al., Maturitas 2006 55: 76-81.

Senior Physician Dr. Markus Lipovac
(Department for gynecology, General Public Teaching Hospital

«In contrast to soy, in addition to the active components of genistein and daidzein, red clover also contains their precursors biochanin A and formonenetin. In this study, for the first-time detailed data was collected on the metabolization of a red clover extract (MF11RCE®) and the bioavailability of its metabolites in oral administration. The results confirm that a single daily dose of 80mg red clover extract is suitable for the long-term and reliable treatment of menopausal symptoms.»

Lipovac M. et al., Fitoterapia 2015 Sep 105: 93-101.


Take 1 tablet per day with something to drink or after a meal. Give MENOPEARL® some time, because the effect does not start immediately. MENOPEARL® should be taken for at least 2 months so that the supportive effect can develop. MENOPEARL® is free of animal components and lactose.